Dr. Luis Vargas

 

Education:

Post-Doctoral (1969), New York University (Dr. Y.E. Rhodes)
PhD (1963), Chemistry; University of Madrid, Spain
MS (1960), Catholic University of Chile

Teaching Philosophy:

Try to inspire student, to reach for their full potential

Research Interests:

  1. Organo-Silicon Chemistry:

    1. Reactivity of Tris(trimethylsilyl) phosphite: TMSP

      1. Use of Tris (trimethylsilyl) phosphite in the preparation of N-mustard-bis-phosphonic acids as potential bone chemotherapy agents. Balakumar, Thayaparan (QCC student); Vargas, Luis: Stephani, Ralph. Poster presentation, 226 th ACS National Meeting, New York, September 7-11 2003. Poster presentation, 36 th Middle Atlantic Regional Meeting of the ACS, Princeton, NJ. June 8-11, 2003.

      2. Synthesis of 3-tert-butyl-1(1-adamantyl) aziridinone and cleavage with Tris (trimethylsilyl) phosphite. Mobin, Shazim (QCC Student); Vargas, Luis; Stephani, Ralph. Presented at the 52 nd Undergraduate Research Symposium, Queensborough Community College, May 1, 2004. Presented at the 27 th Silicon Symposium, University of Pennsylvania May 20, 2004

      3. Synthesis of 1, 3-di-tert-butyl-butylaziridinone and reaction with Tris (trimethylsilyl) phosphite. Jian, Yang (QCC Student), Vargas, Luis; Stephani, Ralph. Presented at the 53 rd Undergraduate Research Symposium, Stony Brook, State University of NY, May 7, 2005. Presented at the 37 th ACS Middle Atlantic Regional Meeting MARM 2005, Rutgers University, May22-25, 2005 and 230 th ACS Meeting, Washington August 28- September 1, 2005.

      4. Preparation of the N-mustard-bisphosphonic acid of Bicine with TMSP. Ji S. Suh (QCC Student), Vargas, Luis; Stephani, Ralph. Presented at the 53 rd Undergraduate Symposium, Stony Brook, State University of NY, May 7, 2005. Presented at the 37 th ACS Middle Atlantic Regional Meeting MARM, Rutgers University, May 22-25, 2005.

    2. Synthesis and Reactivity of Bis (trimethylsilyl) trimethylsilyloxymethylphosphonite: a useful reagent for the introduction of the hydroxymethylphosphinate group.

  2. Organophosphorus chemistry: Synthesis and biochemistry of methylene analogs of natural phosphates (early published work):

    1.  
      1. Rosenthal, A.F., Vargas, L.A., and Han, S.C.H. (1972).Synthesis of optically active diether phosphonate analogs of lecithin, Biochem. Biophys. Acta, 260: 269.

      2. Rosenthal, A.F., and Vargas, L.A. (1981). A synthetic phosphonate-phosphinate liponucleotide analogue, J. Chem. Soc., Chem. Commun.: 976.

      3. Vargas, L.A., Li, X.M., and Rosenthal, A.F. (1984). Inhibition of platelet phosphatidylinositol synthetase by an analog of CDP-diacylglycerol, Biochem. Biophys. Acta, 796: 123.

      4. Vargas, L.A. Glycerophospholipids: Handbook Organophosphorus Chemistry, Ed.R.Engel M.Dekker 1992

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