Dr. Heedong Yun

 

EDUCATION

  • Columbia University, Ph.D. in Chemistry, 2006 (Advisor: Prof. Samuel J. Danishefsky)
  • Columbia University, M.Phil. in Chemistry, 2005 (Advisor: Prof. Samuel J. Danishefsky)
  • Columbia University, M.A. in Chemistry, 2003 (Advisor: Prof. Samuel J. Danishefsky)
  • Seoul National University (Korea), B.S. in Chemistry with Honor and Summa cum laude, 1999 (Advisor: Prof. Eun Lee)

PROFESSIONAL EXPERIENCE

  • Adjunct Assistant Professor, Queensborough Community College, CUNY (2009-present)
  • Senior Research Scientist, Pfizer (2009-present)
  • Senior Research Scientist, Wyeth (2006-2009)
  • Graduate Research Assistant, Columbia University (2001-2006)
  • Undergraduate Research Assistant, Seoul National University, Korea (1998-1999)

PATENTS

  • Danishefsky, S. J.; Yun, H.; Chou, T.-C. “Compositions and Methods for treating cancer or a neurotrophic disorder”, WO 2008/103916 A2.
  • Lee, L, S-U; Stephenson, K. K.; Fahey, J. W.; Parsons, T. L.; Lietman, P. S.; Andrade, A. S.; Yun, H.; Danishefsky, S. J.; Flexner, C. “A Component of Ginseng Arrived By Total Chemical Synthesis Potently Induces Cancer Chemoprotective and Antioxidant Phase 2 Enzymes”, US patent application, 2009, to be filed.

AWARDS

  • Yunam Culture Foundation Fellowship (1995-1999)
  • ACS Medicinal Chemistry Division Graduate Travel Fellowship (2005)
  • ACS Organic Chemistry Division Graduate Travel Fellowship (2005)
  • Columbia University Faculty Fellowship (2001-2006)
  • Eli Lilly Pre-Doctoral Fellowship (2003-2006)

MEMBERSHIPS

  • American Chemical Society (2004-present)
  • Korean American Society in Biotech and Pharmaceuticals (2006-present)

PUBLICATIONS

  1. Yun, H.; Danishefsky, S. J. “A Straightforward Synthesis of Panaxytriol: An Active Component of Red Ginseng”, J. Org. Chem., 2003, 68, 4519.
  2. Yun, H. “Chemoselective Reduction by Cp2Zr(H)Cl”, Aust. J. Chem., 2004, 57, 383.
  3. Yun, H. “Dimethyl(methylene)ammonium salt – Mannich reagent”, Synlett, 2004, 7, 1321.
  4. Yun, H.; Danishefsky, S. J. “Toward the total synthesis of Xestocyclamine A”, 39th National Organic Symposium, Salt Lake City, Utah, 2005, Abstract D92.
  5. Yun, H.; Danishefsky, S. J. “A Protocol to Accomplish ‘Homo-Robinson’ Annulation: Application to the Guanacastepene Problem”, 230th ACS Meeting, Washington, DC, 2005, Abstract MEDI 146.
  6. Yun, H.; Meng, Z.; Danishefsky, S. J. “Enantiotopic Synthesis of Natural Products: Merrilactone and Guanacastepene”, Heterocycles, 2005, 66, 711.
  7. Yun, H.; Chou, T-C.; Dong, H.; Tian, Y.; Li, Y-M.; Danishefsky, S. J. “Total Synthesis as a Resource in the Drug Discovery: The First In Vivo Evaluation of Panaxytriol and its derivatives”, J. Org. Chem., 2005, 70, 10375.
  8. Mandal, M.; Yun, H.; Dudley, G. B.; Lin, S.; Tan, D. S.; Danishefsky, S. J. “Total Synthesis of Guanacastepene A: A Route to Enatiomeric Control”, J. Org. Chem., 2005, 70, 10619.
  9. Yun, H.; Danishefsky, S. J. “A Protocol to Accomplish ‘Homo-Robinson’ Annulation: Application to the Guanacastepene Problem”, Tetrahedron Lett., 2005, 46, 3879.
  10. Yun, H.; Gagnon, A.; Danishefsky, S. J. “Toward the Synthesis of Xestocyclamine A: Investigation of Double-Michael Reaction and Direct Aza Diels-Alder Reaction”, Tetrahedron Lett., 2006, 47, 5311.
  11. Cheong, P. H-Y.; Yun, H.; Danishefsky, S. J.; Houk, K. N. “Torsional Steering Controls the Stereoselectivity of Epoxidation in the Guanacastepene A Synthesis”, Org. Lett., 2006, 8, 1513.
  12. Yun, H. “b-Propiolactone”, Encyclopedia of Reagents for Organic Synthesis, 2008 (DOI: 10.1002/047084289X.rp269.pub2).
  13. Ng, F.; Yun, H.; Lei, X.; Danishefsky, S. J.; Fahey, J.; Stephenson, K.; Flexner, C.; Lee, L. “(3R,9R,10R)-Pnanaxytriol: a molecular-based nutraceutical with possible application to cancer prevention and treatment”, Tetrahedron Lett., 2008, 49, 7178.
  14. Lee, L, S-U; Stephenson, K. K.; Fahey, J. W.; Parsons, T. L.; Lietman, P. S.; Andrade, A. S.; Yun, H.; Danishefsky, S. J.; Flexner, C. “Induction of chemoprotective phase 2 enzymes by ginseng and its components”, The IXth World Conference on Clinical Pharmacology and Therapeutics, 2008, Poster Number T2T082.
  15. Lee, L, S-U; Stephenson, K. K.; Fahey, J. W.; Parsons, T. L.; Lietman, P. S.; Andrade, A. S.; Yun, H.; Danishefsky, S. J.; Flexner, C. “Induction of chemoprotective phase 2 enzymes by ginseng and its components”, Planta Medica, 2009, 75, 1129.
  16. Mattes, J.; Yun, H.; Haydar, S.; Andrae, P.; Robichaud, A. “Synthesis and spectroscopy of several 5-cyclic amine-3-arylsulfonylindazoles”, 238th ACS Meeting, Washington, DC, 2009, Abstract ORGN 199.
  17. Yun, H.; Haydar, S.; Andrae, P.; Robichaud, A.; Zhang, J.; Kramer, A.; Smith, D.; Huselton, C.; Graf, R.; Aschmies, S.; Schechter, L.; Comery, T. “5-Cyclic amine-3-arylsulfonylindazoles as novel 5-HT6 receptor ligands”, 238th ACS Meeting, Washington, DC, 2009, Abstract MEDI 318.
  18. Haydar, S.; Yun, H.; Staal, R. G. W.; Hirst, W. D. “Small molecule protein-protein interaction inhibitors as therapeutic agents for neurodegenerative diseases”, Annual Reports in Medicinal Chemistry, 2009, 44, 51.
  19. Haydar, S.; Yun, H.; Andrae, P.; Mattes, J.; Zhang, J.; Kramer, A.; Smith, D.; Huselton, C.; Graf, R.; Aschmies, S.; Comery, T.; Robichaud, A. “5-Cyclic amine-3-arylsulfonylindazoles as novel 5-HT6 receptor antagonists”, J. Med. Chem., 2009, submitted.

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