Trapping the Enzyme-Catalyzed Reactions using Different Approaches of X-Ray Crystallography

Start Date: February 01 2018 - 05:30 PM

End Date: February 01 2018 - 10:00 PM

Audience: Student, Faculty and Staff

Category: Club Event

Location: S-112

Description:

The QCC student affiliates of the American Chemical Society & the Chemistry Club proudly sponsors the Long Island subsection of the NY-ACS seminar of Dr. Rakhi Agarwal, Department of Chemistry, Nassau Community College, Garden City, New York 11530-6793

Title of Talk: "Trapping the Enzyme-Catalyzed Reactions using Different Approaches of X-Ray Crystallography".

Abstract: Molecular details of substrate recognition, binding, and catalysis plays an important role in understanding the fundamental enzyme-catalyzed reactions.  However, co-crystal structure determination of enzyme-substrate complexes can be challenging due to photoelectric effects of X-ray that can catalyze the reaction in-situ leading to the product formation. Here, two approaches have been presented; first, the co-crystal determination of one of the most poisonous “Botulinum neurotoxin” (BoNT) with its neuronal substrate-cum-inhibitor “VAMP” using traditional X-ray Crystallography and, second, determination of crystal structure of Stachydrine-demethylase (stc2) using X-ray free-electron laser using drop-on-demand Serial Femtosecond Crystallography.

All are welcome!

Directions to QCC

After dinner seminar: At a nearby restaurant, $25 per person. Co-sponsors-STEM academy, STEM Research Club, CSTEP Club, Science Research Alliance, Haitian Club, Biology Club, Students' Health Club, Environmental Sustainability Club, ASAP Club, Korean Student Association, Lambda Sigma Phi Theta Kappa, SACNAS QCC chapter, Asian Society

 


Contact Name: Marlon Moreno

Contact Phone: 718.281.5017

Contact Email: mmoreno@qcc.cuny.edu

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